The Use of Ginseng to Treat Disturbances of Sexual Hormones in the Ovaries Caused by Chemical Doses of Doxorubicin (Drug)

(Anas Abdulwahab Taweelh)

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Abstract

Natural pharmaceutical compounds are relied upon for the treatment of many diseases due to their capacity to possess natural ingredients with medicinal properties that can treat side effects resulting from the toxicity of chemical compounds, such as drugs that treat cancer. We prefer to use ginseng, which is well known for the treatment of stubborn infertility cases and hormonal disorders associated with menopause, hence the importance of this study and the possibility of benefiting from the use of ginseng to treat negative side effects resulting from the use of the drug Doxorubicin. Doxorubicin is a widely-used anti-cancer drug, but it causes a number of negative side effects when treating tumours, including its effect on Graafian follicles and corpus luteum bodies, which play a major role in ovarian activity. We conclude that ginseng is able to maintain near-normal levels of sex hormones despite the presence of the toxic effect of Doxorubicin on ovarian activity. This is due to ginseng’s beneficial effect on the abnormal stimulation of gonadal cells or the increase in hormonal secretion (FSH & LH). Ginseng is also able to stimulate the genes responsible for producing ovarian hormones by mimicking their receptors instead of their original complex. This might result in an improvement in the number of ovulation phases.
KEYWORDS
Corpus luteum, cytotoxic, graafian follicle, pituitary gland, progesterone, sex hormones

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References

Ahmad, N., Gupta, P. and Cicogrge, K. (2009). Sub-acute toxicity or cypermethrin in rats. Journal Environ Biol, 10(3), 309–17.
Aljamal, B. (2010). Iidarat alghidha waldawa wadawruha fi tanzim aldawa 'The food and drug administration and its role in drug regulation'. Amman Journal of Medicine, 12(6), n/a. [in Arabic] 
Andreeva, E., Borovskaia, T., Fommina, T. and Filippova, M. (2002). Late effects of damaging action of doxorubicin on reproductive system and progeny of rats. Journal Antibiotics and Chemotherapy, 37(5), 32–34.
Baquiran, D. and Gallagher, J. (1998). Lippincott's Cancer Chemotherapy. Philadelphia: Lippincott, Handbook.
Basch, E.M. and Ulbricht, C.E. (2005). Natural Stand Herb and Supplement. Mosby St., U.S.A: Louis, Handbook. 
Borovskaya, T.G. and Goi'dberg, E.D. (2000). Effects of anthracyclines on reproductive function in rats. Journal Boil and Med., 130(11), pages1066–8. DOI: 10.1007/BF02688180
Bronson, F.H. and Macmillan, B. (2012). 7 - Hormonal Responses to Primer Pheromones in pheromones and reproduction in mammals vandenbergh. Journal Academic Press, n/a(n/a), 175–97. DOI: 10.1016/B978-0-12-710780-6.50013-3
Cunningham, J., Sharman, V., Hawkes, A.P., Goodwin, F.J. and Marsh, F.P. (2005). Oestrogen-like effect of ginseng. Journal British Medical, Department of Nephrology, the London Hospital, 281(25), n/a.
Desaulniers, J. (2011). Gynecologist, Menopause. Canada: Centre Hospitalier Fleury in Le College Québec. 
Dhimish, A.S. (1997). Mufradat Alnabatat Altibiyat Waturuq Almuealajat Biha 'Vocabulary of Medicinal Plants and Methods of Treatment'. Damascus: Petra House. [in Arabic]
Gaeddert, A. (2011). Healing Immune Disorders Natural Defense- Building Solutions. California: North Atlantic Books Berkeley.
Gao, Q.G., Chen, W.F., Xie, J.X. and Wong, M.S. (2009). Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. Journal Neurochemistry, 109(5), 1338–47. DOI:10.1111/j.1471-4159.2009.06051.x
Guyton, A.C. (1991). Textbook of Medical Physiology. U.S.A: W.B. Saunders. 
Hadidi, S. (1995). Fizyulujia Alghudad Alsumu 'Endocrine Physiology'. Damascus: Dar Tlass. [in Arabic]
Heli, J., Roy, P. and Kalicki, R. (2009). Ginseng. Journal Pennington Nutrition Series, Division of Education from Pennington Biomedical Research Center, in Baton Rouge, Louisiana, n/a(8), n/a.
Husayn, M. (2009). Aljadid Fi Altibi Albadil 'New in Alternative Medicine'. Aleppo: Al Hafez House for Books. [in Arabic]
Jeffrey, D. (2000). PDR for Herbal Medicines. Canada: Published by Medical Economics Company.
Jung, J.H., Park, H.T., Kim, T., Jeong, M.J., Lim, S.L., Nat, S.Y., Cho, I.H., Kang, S.S., Moon, C.J., Kim, J.C., Kim, S.H. and Bae, C.S. (2011). Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries. Journal Ginseng Research, 35(2), 250–5. DOI: 10.5142/jgr.2011.35.2.250
Lee, Y.J., Jin, Y.R., Lim, W.C., Ji, S.M., Choi, S., Jang, S. and Lee, S.K. (2003). A ginsenoside-Rh1 a component of ginseng saponin activates estrogen receptor in human breast carcinoma MCF-7 cells. Journal of Steroid Biochemistry and Molecular Biology, 84(4), 463–8. DOI: 10.1016/S0960-0760(03)00067-0
Leung, L.W. and Tsai, W.A. (2010). Pharmacology of ginsenosides: a literature review. Journal Chinese Medicine, 5(20), n/a. DOI:10.1186/1749–8546-5–20
Lowry, W. (2007). Unwanted effects of cytotoxic drugs bibliographic citation. Journal Prescriber's, 10(n/a), 132–4.
Maria, A.P., Monica, M., Luigi, S., Ioannis, A.C. and Lucrezia, B. (2022). Ancient herbal therapy: A brief history of Panax ginseng. Journal of Ginseng Research, 47(3), 359–65. DOI:10.1016/j.jgr.2022.03.004
Mosby, S. (2006). Book of Herbs and Natural Supplements. 3nd edition. London: Skid More-Roth.
Pak, S.C., Kim, S.E., Oh, D.M., Shim, K.M., Jeong, M.J., Lim, S.C., Nah, S.Y., Park, S.H., Kang, S.S., Moon, C.J., Kim, J.C. and Kim, S.H. (2009). Effects Korean red ginseng extract in estradiol ovary murine model. Journal Archives of Pharmacal Research, 32(n/a), 347–52. DOI: 10.1007/s12272-009-1306-y
Perth, P.L. (2022). Product Information Adriamycin. Australia: Pfizer.
Rose, D. and Davis, T. (2000). Effects of adjuvant chemohormonal therapy on the ovarian and adrenal function of breast cancer patients. Journal Cancer- Research, 40(n/a), 4043–7.
Samaan, N.A., Deasis. D.N., Buzdar, A.U. and Blumenschein, G.R. (1978). Pituitary-ovarian function in breast cancer patients on adjuvant chemotherapy. Journal Cancer, 41(6), 2084–7. DOI: 10.1002/1097-0142(197806)41:6<2084::aid-cncr2820410603>3.0.co;2-y
Shamberger, R., Sherins, R., Ziegler, J., Glatstein, E. and Rosenberg, S. (2001). Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma. Journal Natl Cancer, Inst, 67(6), 1213–8.
Shima Y. (2000). Quantitative study on the effect of oncostatic toxicity on murine fertility. Journal Nippon, 46(7), 589–96.
Stephanie, S. and Faubion, M.D. (2022). The Menopause Solution. U.S.A: Mayo Clinic Press.
Taweelh, A. (2019). Study of toxic effects of adriamycin drug on female sex cells and comparing honey and ginseng ability to treat these effects. International Journal of Pharmaceutical Care and Health, 2(106), n/a. 
Taweelh, A. (2022). Aldawr alwiqayiyu limazij min aleasal walghidha almalakii mae judhur eushbat aljinsingh aitijah altaathirat alsmyt aldawayiyat alati tuhdthha aleilajat alkymyayy (doxorubicin) fi alkhalaya aljnsyt alunthawia 'The protective role of a mixture of honey and royal jelly with ginseng roots against the pharmacological toxicological effects of chemical treatments (doxorubicin) on female sexual cells'. Researches Journal of Aleppo University, Basic Science Series, n/a(155), n/a. [in Arabic]
Taweelh, A. and Kassem, M. (2014). Preventing the side effects of adriamycin drug on histological structure of the ovaries in Syrian Hamster using honey and royal jelly mixed with the roots of the ginseng herb. Science Journal of King Abdul Aziz University, 25(2), 89–121. DOI: 10.4197/Sci.25-2.6
Taweelh, A. and Kassem, M. (2015). The role of honey with royal jelly in protecting the graafian follicles from the toxicity of the adriamycin drug. International Journal of Pharmacy and Pharmaceutical Sciences, 7(4), n/a.
Taweelh, A., Kassem. M. and Basal, A. (2013). Dirasat tathir eaqar adriamycinealaa albinyat alnasijiat liljaribat alnaadijat fi mabayid alhamistar alsuwri 'The adriamycin effect on the histological structure of the mature follicles in the ovaries of the Syrian hamster'. Researches Journal of Aleppo University, Basic Science Series, n/a(91), n/a. [in Arabic]
Tawele, A., Kassem, M. and Khanji, Y. (2010). Study of the effect of Adriamycin on the graffian follicles and oocytes in albino mice and compare it with sexual activity in women taking this drug. Science Journal of King Abdul Aziz University, 22(2), 217–50. DOI: 10.4197/sci.22-2.17 
Tian, M., Man, H., Xin, Li, P., Jiang, X., Man, M., Ding, D. and Wen, J. (2008). Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis. Journal Chinese Medical, 121(15), 1394–17. DOI: 10.1097/00029330-200808010-00012
Yaho, J. and Mami, K. (2012). Menopausal symptoms comparative effectiveness review of therapies. Journal Effect Ivehealthcare, Aheq, 3(n/a), n/a.