Evaluation of Olive Oil Ester-Buffer System for the Development of Piroxicam Micro-Emulsion

(Bandar Issa Dhbaib)

---

Abstract

The objective of the current study was to assess the prospective of formulating piroxicam micro-emulsion using olive oil ester PEG8211;buffer system. Surface tension, interfacial tension, spreading coefficient, miscibility were determined for different media containing drug, olive oil, phosphate buffer (pH 4, 6, 7.4), surfactants alone and combination using standard protocols. Micro-emulsion was prepared to assess the feasibility of the selected medium. The results observed indicate that the oil phase has lower surface tension when compared to the olive oil ester buffer system. Further, it was observed that the drug has no effect on the surface tension and interfacial tension of the olive oil ester-phosphate buffer system. This behavior of piroxicam confirms the feasibility of olive oil ester-buffer system as a potential vehicle for the formulation of micro emulsion. Key Words: Micro-emulsion, olive oil ester, Piroxicam, Phosphate buffer, Surface tension.
PDF

References