A Histopathologic Study of the Protective Effect of Grape Seed Extract Against Experimental Aluminum Toxicosis in Male Rat

(Mustafa Mansour Haseeb, Fahd and Abdullah Hezbe Yahya Ahmed Hussein)

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Abstract

Grape seed extract is considered as a concentrated source of polyphenols, more specifically polyhydroxylated flavan-3-ols. It is increasingly receiving attention as dietary supplement for the homeostatic management of inflammation, to support detoxification, and for anticancer, antioxidation, weight loss, and other benefits. The present pathologic study was carried out to investigate the microscopic changes related to the protective effect of supplementation with grape seed extract (GSE) against the induced lesions due to experimental intoxication with aluminum chloride (AlCl3) as one of the common environmental pollutants. For this aim, 4 groups of male rats (-ve control, +ve control for GSE supplementation, +ve control for AlCl3 intoxication, and experimental group of concurrent administration of GSE and Al Cl3), were used. At the end of the experiment (8weeks) the rats of all groups were necropsied and tissues specimens were collected and processed for the following comparative histopathologic examination. The obtained microscopic findings, revealed an alleviating effect of GSE against AlCl3-induced lesions in various body organs of the rats. Key Words: Grape seed extract; Aluminum; Aluminum chloride; oxidants; Antioxidant; neurotoxicosis; hepatotoxicosis; nephrotoxicosis; protective effect.
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