Scientific Journal Of King Faisal University
Basic and Applied Sciences

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Scientific Journal of King Faisal University / Basic and Applied Sciences

The Relationship Between Cadmium Levels and Testosterone Levels in a Sample of Aleppo City Residents

(Mohammad Amer Salaho and Mahmoud Kassem)

Abstract

This study aimed to determine the blood concentration levels of cadmium in a sample of residents of Aleppo and to correlate them with their testosterone concentration levels. The experiment was conducted using 75 participants divided into 3 groups, averaging 25 participants per group: a group of people who work with electrical generators, a group of smokers, and a control group. The results showed higher average cadmium concentration levels in all groups, including the control group, compared with the normal levels of cadmium concentration in the body. The average concentration levels per group were 88.48 µg/l, 82.32 µg/l, and 19.84 µg/l, respectively. The results also showed lower mean testosterone concentrations in both the group of people who work with electrical generators (5.53 ng/ml) and the group of smokers (4.43 ng/ml) when compared with the control group (7.59 ng/ml). Using the Pearson correlation coefficient, a correlation was found between cadmium concentrations and testosterone concentrations (P = 0.05).

KEYWORDS
Cadmium, electrical generators, men's fertility, sandwich complex, smoking, testosterone

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References

Ayad, A., Mokhtar, B. and Benbarek, H. (2018). The ability of human electrochemiluminescence immunoassay to measure testosterone and progesterone in plasma ovine. Malaysian Journal of Veterinary Research, 9(1), 22–32. 
Bernhard, D., Rossman, A., Henderson, B., Kind, M., Seubert, A. and Wick, G. (2006). Increased serum cadmium and ctrontium levels in young smokers effects on arterial endothelial cell gene transcription. American Heart Association, 26(4), 833–8.
El-Demerdash, F.M., Yousef, M.I., Kedwany, F.S. and Baghdadi, H.H. (2004). Cadmium induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and b-carotene. Food Chem Toxicol, 42(10),1563–71.
Elgawish, R.A.R. and Ghanem, M.E. (2014). Effect of long-term cadmium chloride exposure on testicular functions in male albino rats. Am J Anim Vet Sci, 9(4), 182–8.
Goering, P.L., Waalkes, M.P. and Klaassen, C.D. (1995). Toxicology of cadmium. In: R.A. Goyer, and M.G. Cherian (eds.) Toxicology of Metals. Berlin, Germany: Springer.
Husain, E.A. (2016). Taqdir almadkhul alyawmii min alrasas walkadmiuwm alnnatij min aistihlak lahm lanshun aldijaj fi madinat dimashqa 'Estimation of the daily intake of lead and cadmium resulting from consumption of chicken luncheon meat in Damascus'. Syrian Journal of Agricultural Research, 3(1), n/a. [in Arabic].
Ibrahim, Dina. (2014). Dirasat Iimkaniat Murakamat Bed Al'anwae Alnabatiat Almazrueat fi Haram Musfat Banyas Lileanasir Althaqilati ' Study of the Possibility of Accumulating Some Plant Species Cultivated on the Campus of Banias Refinery for Heavy Metals'. Master Thesis, Tishreen University, Lattakia, Syria. [in Arabic].
Ige, S.F., Olaleye1, S.B., Akhigbe, R.E., Akanbi, T.A., Oyekunle, O.A. and Udoh, S. (2012). Testicular toxicity and sperm quality following cadmium exposure in rats: Ameliorative potentials of Allium cepa.  Journal of Human Reproductive Sciences, 5(1), 37–42. 
Jurasovic. J., Cvitkovic, P., Pizent, A., Colak, B. and Telisman, S. (2004). Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subjects. Biometals, 17(6), 735–43.
Kanwar, U., Chadha, S., Batla, A., Sanyal, S.N., and Sandhu, R. (1988). Effect of selected metal ions on the motility and carbohydrate metabolism of ejaculated human spermatozoa. Indian Journal of Physiology and Pharmacology, 32(3), 195–201.
Lee, J.W., Kim, Y.E., Kim, YO., Yoo, H. and Kang H.T. (2020). Cigarette smoking in men and women and electronic cigarette smoking in men are associated with higher risk of elevated cadmium level in the blood.
J. Korean Med Sci, 35(2), 1–11.
Liu, J., Qu, W. and Kadiiska, M.B. (2009). Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol, 238(3), 209–14.
Martin, S. and Griswold, W. (2009). Human health effects of heavy metals. Environ Sci Technol, 15(2), 146–56.
Mendiola, J., Moreno, J.M., Roca, M., Vergara-Juarez, N., Martinez-Garcia, M.J., Garcia-Sanchez, A., Elvira-Rendueles, B., Moreno-Grau, S., Lopez-Espin, J.J., Ten, J., Bernabeu, R. and Torres-Cantero, A.M. (2011). Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: A pilot study. Environmental Health, 10(1), 1–6.
Moffat, A.C., Osselton, M.D., Widdop, B. and Watts, J.  (2011). Clarke’s Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material, 4th edition. London, United Kingdom: Pharmaceutical Press.
Musa, A., Garba. M., Yakasai. I.A. and Odunola. M.T. (2011). Determination of blood levels of cadmium and zinc in humans from Zaria, Nigeria. Woaj Ltd, 2(n/a), 49–54.
Saaranen, M., Kantola, M., Saarikoski, S. and Vanha-Perttula, T. (1989). Human seminal plasma cadmium: Comparison with fertility and smoking habits. Andrologia, 21(2), 140–5.
Telisman, S., Cvitkovic, P., Jurasovic, J., Pizent, A., Gavella, M. and Rocic, B. (2000). Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men. Environmental Health Perspectives, 108(1), 45–53.
Thijssen, S., Cuypers, A., Maringwa, J., Smeets, K., Horemans, N., Lambrichts, I. and Van-Kerkhove, E. (2007). Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys. Toxicol, 236(2), 29–41.
Waisberg, M., Joseph, P., Hale, B. and Beyersmann, D. (2003). Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicol, 192(2), 95–117.
Wang, C., Catlin, D.H., Demers, L.M., Starcevic, B. and Swerdloff, R.S. (2004). Measurement of total serum testosterone in adult men: Comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. J. Clin Endocrinol Metab, 89(2),534–43.
Zeng, X., Jin, T., Buchet, J.P., Jiang, X., Kong, Q., Ye T., Bernard, A. and Nordberg, G.F. (2004). Impact of cadmium exposure on male sex hormones: A population-based study in China. Environ Res, 96(3), 338–44.
Zeng, X., Jin, T., Zhou, Y., and Nordberg, G. F. (2003). Changes of serum sex hormone levels and MT mRNA expression in rats orally exposed to cadmium. Toxicology, 186(2), 109–118.
Zeng, X., Lin, T., Zhou, Y. and Kong, Q. (2002). Alterations of serum hormone levels in male workers occupationally exposed to cadmium. Journal of Toxicology and Environmental Health, 65(7), 513–21.
Zirkin, B.R. and Papadopoulos, V. (2018). Leydig cells: Formation, function, and regulation. Biology of Reproduction, 99(1), 101–11.