FURO[3,4-B]QUINOLONE COMPOUNDSAS ANTIBACTERIAL AGENTS

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FURO[3,4-B]QUINOLONE COMPOUNDSAS ANTIBACTERIAL AGENTS

  • US 11,731,980B1

  • الصحة - Health

  • 2023

  • مكتب البراءات الأمريكي - US Patent Office

  • Christophe Tratrat, Al-Ahsa(SA); Michelyne Haroun, Al-Ahsa(SA)

  • The furo[3,4-b]quinolone compounds represent a promising new class of antibacterial agents with significant potential to address the growing threat of drug-resistant bacteria. These compounds exhibit several key advantages: Broad-spectrum activity: They are effective against gram-positive and gram-negative bacteria, as well as tuberculosis mycobacteria14. Potency against drug-resistant strains: The compounds show strong activity against resistant bacteria like MRSA (Methicillin-resistant Staphylococcus aureus) and VRSA (Vancomycin-resistant Staphylococcus aureus)14. Novel molecular target: Their mechanism of action involves targeting DNA Gyrase B, which may help overcome existing resistance mechanisms26.