عـرض براءة الإختـراع

Polymeric clotrimazole biofilm for the treatment of otomycosis

• رقــم البراءة

  US 11,844,781 B1

• المجـال العلمى

  الصحة - Health

• سنة الإصدار

  2023

• مكتـب التسجيـل

  مكتب البراءات الأمريكي - US Patent Office

• أسماء المخترعين

  Khalaf Ali; Mai Mostafa (Al-Ahsa, SA), Abd El-Lateef Ahmed; Hany Mohamed (Al-Ahsa, SA), Abu-Dief Mohammed; Ahmed Mohammed (Al-Madina Al-Mounawara, SA), Elsayed Karamany; Amr Embaby (Assuit, EG), Mahmoud Abdelmagid; Mahmoud Ibrahim (Assuit, EG), Saddik Ibrahim; Mohammed Sherif (Sohag, EG), Abd Eltwab Morsy; Ali Khames (Sohag, EG)

• نبذة عن البـراءة

  The polymeric clotrimazole biofilm for the treatment of otomycosis contains clotrimazole or a pharmaceutically acceptable salt thereof as the active pharmaceutical ingredient in a polymer biofilm thug delivery vehicle. The polymer may be a bio compatible polymer, such as hydroxypropylmethylcellulose (HPMC). Propylene glycol may be added to the mixture as a plasticizer to promote formation of the film. The drug and the polymer may be solvated in a casting solvent and then mixed in a 1:3 ratio of drug:polymer. About 15% propylene glycol may be added to the mixture, which is then heated at 40° C. until a thin, flexible film forms. A round, knife-thick patch of the biofilm may be applied to the patient's ear through the external canal and over the tympanic membrane.