7-ISOPROPYL 1-ETHYL/METHYL 3-(SUBSTITUTED BENZOYL)-2-SUBSTITUTED INDOLIZINE-1,7-DICARBOXYLATES AS ANTI-TUBERCULAR AGENTS

hawafiz kfu icon
book cover

7-ISOPROPYL 1-ETHYL/METHYL 3-(SUBSTITUTED BENZOYL)-2-SUBSTITUTED INDOLIZINE-1,7-DICARBOXYLATES AS ANTI-TUBERCULAR AGENTS

  • US 11,807,640B1

  • الصحة - Health

  • 2023

  • مكتب البراءات الأمريكي - US Patent Office

  • Katharigatta N. Venugopala, Al-Ahsa (SA); Bandar Aldhubiab, Al-Ahsa (SA); Mohamed A. Morsy, Al-Ahsa (SA); Mahesh Attimarad, Al-Ahsa (SA); Anroop B. Nair, Al-Ahsa (SA); Nagaraja Sreeharsha, Al-Ahsa (SA); Christophe Tratrat, Al-Ahsa (SA); Sandeep Chandrashekharappa, Lucknow (IN); Melendran Pillay, Durban (ZA); Pran Kishore Deb, Amman (JO); Sheena Shashikanth, Mysore (IN).

  • The substituted indolizine dicarboxylates are antibacterial agents. The emergence of drug-resistant bacteria calls for constant development of new antibacterial agents with the aim of generating medicaments that are potent against drug-sensitive and resistant bacteria and are well tolerated. The present compounds are not only new but have very valuable antimicrobial properties. These compounds showed a broad spectrum of activity against tuberculosis mycobacteria. Based on their pharmacological profiles, the present compounds may find important clinical applications for severe infectious diseases and tuberculosis.