Substituted pyrimido[4,5-b]indoles as CK2 inhibitors

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Substituted pyrimido[4,5-b]indoles as CK2 inhibitors

  • US 12,180,218B1

  • الصحة - Health

  • 2024

  • مكتب البراءات الأمريكي - US Patent Office

  • Haroun; Michelyne (Al-Ahsa, SA), Tratrat; Christophe (Al-Ahsa, SA)

  • Pyrimido[4,5-b]indole compounds, having the formula: ##STR00001## a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The pyrimido[4,5-b]indole compounds, identified as CK2 inhibitors, are useful as anticancer and/or antitumor agents, and as agents for treating other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and other types of diseases such as diabetes, viral infection, neurodegenerative diseases. Please replace the originally-filed Specification with the Substitute Specification submitted herewith. Both a “corrected” copy of the Specification and a “clean” copy of the Substitute Specification are attached hereto. No new subject matter has been incorporated herein.