PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PPAR-GAMMA INHIBITORS

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PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PPAR-GAMMA INHIBITORS

  • US 11,845,743B1

  • الصحة - Health

  • 2023

  • مكتب البراءات الأمريكي - US Patent Office

  • Michelyne Haroun, Al-Ahsa(SA); Christophe Tratrat, Al-Ahsa(SA)

  • The pyrazolidinedione derivatives were found to possess blood glucose-lowering properties. These compounds were designed as potential PPAR-gamma inhibitors, an essential molecular target for clinically used antidiabetic drugs. Owing to their promising anti-hyperglycemic activity, these derivatives may find useful applications for the treatment and/or prevention of obesity, diabetes type I and II, hyperglycemia, and other diseases where PPAR-gamma is implicated, such as cancer, atherosclerosis, and hyperlipidemia.