عـرض براءة الإختـراع

POLYMERIC CLOTRIMAZOLE BIOFILM FOR THE TREATMENT OF OTOMYCOSIS

• رقــم البراءة

  US 11,833,134B1

• المجـال العلمى

  الصحة - Health

• سنة الإصدار

  2023

• مكتـب التسجيـل

  مكتب البراءات الأمريكي - US Patent Office

• أسماء المخترعين

  Mai Mostafa Khalaf Ali, Al-Ahsa (SA); Hany Mohamed Abd El-Lateef Ahmed, Al-Ahsa (SA); Ahmed Mohammed Abu-Dief Mohammed, Al-Madina Al-Mounawara (SA); Amr Embaby Elsayed Karamany, Assuit (EG); Mahmoud Ibrahim Mahmoud Abdelmagid, Assuit (EG); Mohammed Sherif Saddik Ibrahim, Sohag (EG); Ali Khames Abd Eltwab Morsy, Sohag (EG)

• نبذة عن البـراءة

  The polymeric clotrimazole biofilm for the treatment of otomycosis contains clotrimazole or a pharmaceutically acceptable salt thereof as the active pharmaceutical ingredient in a polymer biofilm drug delivery vehicle. The polymer may be a biocompatible polymer, such as hydroxypropylmethylcellulose (HPMC). Propylene glycol may be added to the mixture as a plasticizer to promote formation of the film. The drug and the polymer may be solvated in a casting solvent and then mixed in a 1:3 ratio of drug: polymer. About 15% propylene glycol may be added to the mixture, which is then heated at 40°C until a thin, flexible film forms. A round, knife-thick patch of the biofilm may be applied to the patient’s ear through the external canal and over the tympanic membrane.