N-(PYRIMIDO[2,3-B]INDOL-7-YL)ACETAMIDE COMPOUNDS AS ANTIBACTERIAL AGENTS

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N-(PYRIMIDO[2,3-B]INDOL-7-YL)ACETAMIDE COMPOUNDS AS ANTIBACTERIAL AGENTS

  • US 11,773,093 B1

  • الصحة - Health

  • 2023

  • مكتب البراءات الأمريكي - US Patent Office

  • Michelyne Haroun, Al-Ahsa (SA); Christophe Tratrat, Al-Ahsa (SA)

  • The N-(Pyrido[2,3-b]indol-7-yl)acetamide compounds are antibacterial agents. The emergence of drug-resistant bac- teria calls for constant development of new antibacterial agents with the aim of generating medicaments that are potent against drug sensitive and resistant bacteria and are well tolerated. The present compounds are not only new, but have very valuable antimicrobial properties. These com- pounds showed a broad spectrum of activity against gram- positive and gram-negative bacteria, as well tuberculosis mycobacteria. They also showed potent activity against drug-resistant bacteria, such as MRSA and VRSA. The molecular target of these compounds was identified as DNA Gyrase B. Based on their pharmacological profiles, the present compounds may find important clinical applications for severe infectious diseases and tuberculosis.