Substituted pyrido[3′,4′:4,5]pyrrolo[2,3-c]quinolines as CK2 inhibitors
Substituted pyrido[3′,4′:4,5]pyrrolo[2,3-c]quinolines as CK2 inhibitors
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US 11,884,668 B1
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الصحة - Health
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2024
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مكتب البراءات الأمريكي - US Patent Office
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Tratrat; Christophe (Al-Ahsa, SA), Haroun; Michelyne (Al-Ahsa, SA)
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Pyrido[3′,4′:4,5]pyrrolo[2,3-c]quinolone compounds are provided. The pyrido[3′,4′:4,5]pyrrolo[2,3-c]quinolone compounds have the general formula: ##STR00001## where R.sub.1 is H, C(O)OH.sub.4, O or OH: R.sub.2 is H, C(O)OH, C(O)OR.sub.4, or OH: and R.sub.3 is C—C.sub.6 alkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 cyanoalkyl, (CH.sub.2).sub.2-3NR.sub.7R.sub.8, (CH.sub.2).sub.1-2aryl, (CH.sub.2).sub.1-2heteroaryl, C(O)—(CH.sub.2).sub.2-3NR.sub.7R.sub.8, C(O)aryl, C(O)heteroaryl, NH(CH.sub.2).sub.2-3NR.sub.7R.sub.8, NH(CH.sub.2).sub.0-1aryl, NH(CH.sub.2).sub.0-1heteroaryl, NHC(O)—(CH.sub.2).sub.2-3NR.sub.7R sNHC(O)aryl, NHC(O)heteroaryl, NHS(o).sub.2-(CH.sub.2).sub.2-3NR.sub.7R.sub.8, NHS(O).sub.2aryl, NHS(O).sub.2heteroaryl, S(O).sub.2—(CH.sub.2).sub.2-3NR.sub.7R.sub.8, S(O).sub.2aryl, S(O).sub.2heteroaryl, C.sub.3-C.sub.6 cycloalyl, C.sub.3-C.sub.6 halocycloalyl, C.sub.3-C.sub.6 cyanoccloalyl, aryl, or 5- or 6-membered heteroaryl. The compounds are inhibitors of protein kinase CK2 activity.