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SULFASALAZINE-LOADED ZINC OXIDE NANOPARTICLES FOR THE TREATMENT OF ULCERATIVE COLITIS

  • US 11,730,759B1

  • الصحة - Health

  • 2023

  • مكتب البراءات الأمريكي - US Patent Office

  • Hany Mohamed Abd El-Lateef Ahmed, Al-Ahsa (SA); Mai Mostafa Khalaf Ali, Al-Ahsa (SA); Ahmed Mohammed Abu-Dief Mohammed, Al-Ahsa (SA); Mohammed Sherif Saddik Ibrahim, Al-Ahsa (SA); Ali Khames Abd El-Twab Morsy, Al-Ahsa (SA)

  • A composition for treating ulcerative colitis can include zinc oxide nanoparticles and sulfasalazine adsorbed onto a surface of the zinc oxide nanoparticles. The composition can be administered to a patient to treat ulcerative colitis or symptoms associated with ulcerative colitis. The composition can be administered at about 100 mg/kg of zinc oxide nanoparticles and up to about 12.2 mg/kg of sulfasalazine. These compositions exhibit synergistic effects in treating ulcerative colitis.