7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7 tricarboxylates as adenosine receptor active compounds
7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7 tricarboxylates as adenosine receptor active compounds
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US 11,981,673 B1
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الصحة - Health
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2024
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مكتب البراءات الأمريكي - US Patent Office
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Venugopala; Katharigatta N. (Al-Ahsa, SA), Deb; Pran Kishore (Al-Ahsa, SA), Michela; Buccioni (Al-Ahsa, SA), Marucci; Gabriella (Al-Ahsa, SA), Chandrashekharappa; Sandeep (Al-Ahsa, SA), Venugopala; Rashmi (Al-Ahsa, SA)
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Novel 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, identified as adenosine A.sub.3 receptor (A.sub.3AR) modulators, are useful as anti-inflammation, anticancer and/or anti-ischemic agents, and as agents for treating other adenosine overexpression related conditions including rheumatoid arthritis, psoriasis and fatty liver diseases, inflammation, pain, and number of pathological conditions of the central and peripheral nervous systems.