Effects of single doses of Bitis arietans crude venom on serum biochemical parameters in rats

(Ibrahim Abdul Rahman Jamaz)

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Abstract

The acute effect of single intraperitoneal injections of 2 mg/kg and 4mg/kg body weight of Bitis arietans crude venom on serum enzyme and other constituents was evaluated in rats .The snake venom caused within 24hr of the dosing a reduction in the concentration of total serum protein, albumin, uric acid, potassium, magnesium , phosphorus and calcium levels, as well as in the activity of alkaline phosphatase, gamma-glutamyl transferase, aspartate aminotransferase and lactic dehydrogenase. The levels of glucose, cholesterol, urea and creatinine were elevated and the activity of alanine aminotransferase. Serum sodium levels significantly increased in envenomated rats. Serum iron and triglycerides levels and the activity of amylase did not change. B. arietans crude venom caused hepatic, renal and cardiac dysfunction in envenomated rats.
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