Protective Effects of α-Lipoic Acid on Hepatic and Renal Biomarkers and Histological Changes Induced by α−Cypermethrin in Treated Male Rats

(Mohammed A. Al-Omair)

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Abstract

α-Cypermethrin is a synthetic type II pyrethroid insecticide. Earlier works have revealed the argumentative influence of α-cypermethrin on liver and kidney. This work aimed to estimate the potential character of α-lipoic acid in the induced toxicity of α-cypermethrin in the kidney and liver of male albino rats. Examined rats were alienated into four groups as following; α-cypermethrin/α- lipoic acid, α-lipoic acid, α-cypermethin as well as control. The results of this study showed that administration of α- cypermethrin caused a significant increase in the activity of ALT (Alanine Transaminase), AST (Aspartate Transaminase), ALP (Alkaline Phosphatase), the level of bilirubin, urea, uric acid, and creatinine, as well as decreased levels of total protein and albumin. Moreover, the presence of α- lipoic acid alleviates the harmfulness of α-cypermethrin by moderately regularizing these biochemical factors. The biochemical markers were maintained by the histological investigation. Our outcomes proposed that α- lipoic acid might play a defensive role in the induced toxicity of α- cypermethrin in the kidney and liver of treated rats. Key Words: α-Cypermethrin, α- Lipoic acid, Biomarkers, Histology, Liver and kidney, Toxicity.
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