Anti-Adhesion Effect of Some Medical Plant Extracts on Some Bacteria Causing Urinary Tract Infection

(Hero Mohammed Obaid emigrated Ali Shareef)

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Abstract

Urinary tract infection (UTI) is among the commonest human health problems, which may require antibiotic treatment. Recently, bacterial resistance to antibiotic is detected in most of UTIs patients. The aim of the present study was to examine the anti-adhesion properties of five medicinal plant extracts (Nasturtium officinale, Petroselinum crispum, Trigonella foenum-graecum, Nigella sativa, Pimpinella anisum) on some enterobacteriace causing UTI (Escherichia coli, Proteus mirabilis, Klebsiella spp., Pseudomonas aeruginosa).The results indicated that the plants alcoholic extracts had significantly higher anti adhesion effect than the watery one. N. officinale had the highest anti-adhesion effect at 5mg/ml. The inhibition rates for each of E.coli, proteus, kelbsiella and pseudomonas were 51.2, 45.1, 58.5, and 57.9 % when watery extracted; while alcoholic extracts scored 90.2, 91.4, 82.9, 71.1% for the same species, respectively. The lowest inhibition rate was reported in watery extract of T. foenum-graecum. High anti-adhesion effect was noted with N. sativum in both watery and alcoholic extracts. Low inhibition rate was resulted in P. anisum watery extracts while the highest effect resulted from its alcoholic extracts. Variable inhibition rates, moderate to low, were noted in both watery and alcoholic extracts of P. crispum. The conclusion of the investigation was that the alcoholic extracts of N. officinale and T. foenum-graecum have high anti-adhesion effect at 5mg/ml against E.coli, Proteus mirabilis, Klebsiella spp and Pseudomonas aeruginosa. The consequences of this investigation suggest that the extracts of N. officinale and T. foenum-graecum could be used as prophylaxis for preventing the bacterial UTI especially in female with recurrent infection. Key Words: Anti- adhesion, Bacteriuria, Plant extracts, Uroepithelial cells.
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