Role of survivin & soluble intercellular adhesion molecule-1 in sickle cell disease

(Azza Hassan Oboghalah and Ibrahim Sultan and Yasser Khalil Abu Bakr (3))

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Abstract

The prediction of prognosis of an individual with sickle cell anemia could guide therapeutic decision making. Previous studies showed that adhesion molecules contribute to the development of inflammatory vascular complications in some diseases. Other studies showed that survivin and lipoprotein (a) [Lp (a)] enhance the expression of soluble intercellular adhesion molecule-1(s-ICAM-1). Thus, we proposed that survivin, s-ICAM-1 and Lp (a) might affect the risk for complications in patients with sickle cell anemia. The study consisted of 40 patients with sickle cell trait (SCT) and sickle cell disease (SCD) in addition to 33 controls from Al-Hasa province of Saudi Arabia. All laboratory analyses were measured by the standard methods. In the SCD group, both serum survivin and Lp (a) were insignificantly higher than in the other two groups. The patient with the highest survivin concentration didn&8217;t suffer from hemolytic crisis. Patients with clinical complications had insignificantly lower survivin than patients without complications. Consistent with its need during continued production and survival of red blood cells, survivin expression was positively and significantly correlated with MCV, and reticulocytic count. The levels of Lp (a) and s ICAM-1 were significantly correlated with serum creatinine and ALT suggesting a link with endothelial dysfunction. The correlation between Lp (a), survivin and s ICAM-1 was positive but statistically insignificant.
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