Histopathologic Studies on the Effect of Repeated Doses of Dectomax on Some Genital Organs of Female Guinea Pigs

(Mustafa Mansour Haseeb and Fahad Abdullah Hezbe)

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Abstract

Histopathologic studies were carried out in order to detect the adverse effect and tissue alterations in the genital organs of healthy female guinea pigs after weekly repeated injections of variable dose levels of Dectomax (Doramectin). A total of 72 adult female guinea pigs were used for this purpose. They were divided into four groups; non-treated control and other three groups treated with therapeutic dose (0.2 mg/kg. b.wt), double therapeutic dose (0.4 mg/kg. b.wt) and triple therapeutic doses (0.6 mg/kg. b.wt). Microscopic examination revealed minimal or no changes in the genital organs of the female guinea pigs which received a total of 6 weekly repeated therapeutic doses. On the other hand, the repeated injections of double or triple therapeutic doses resulted in remarkable histopathologic alterations dominated by follicular degeneration and necrosis in the ovaries. In addition, there was interstitial edema, congestion and degenerations of the endometrial glands, especially after the 5th and 6th repeated triple doses. It was concluded that the repeated as well as duplication for the therapeutic dose levels lead to some adverse effects on the female genital organs.
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