Comparative Pharmacokinetic Studies of Kanamycin in Camels, Sheep and Goats

(Mohammed bin Hammad Alenzaoa and Abdel Kader Moussa benign)

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Abstract

Pharmacokinetics of kanamycin in camels, sheep and goats were determined following a single IV dose of 5181;g/kg body weight of kanamycin. Plasma concentrations of kanamycin versus time were best fitted to a two-compartment open model with a t1/2 of 6.2, 3.5 and 2.9 hours and volume of distribution of 0.6, 0.28 and 0.18 L/kg for camels, sheep and goats, respectively. In the camel, an increase of kanamycin plasma concentration reoccurred after 7 hours post injection producing a trough-like pattern of t1/2 of 26.3 hours, suggesting that kanamycin is extensively reabsorbed from urinary tract of camel. Due to significant differences in pharmacokinetic parameters of kanamycin between the 3 animals species, extrapolation of doses of drugs from one species to the other should be avoided.
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