Comparative In-Vivo Activities of Diminazene, Suramine, Quinapyramine and Homidium Bromide on Trypanosoma Evansi Infection in Mice

(Hamdan Bin Ibrahim Al-Mohammad)

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Abstract

Chemotherapy and chemoprophylaxis are the main methods of trypanosomal control. This study was done to compare the in vivo efficacy of four commonly used antitrypanosomal drugs. Twenty five Swiss Webstar mice (groups of fives) infected with locally isolated Trypanosoma evansi strains were used. Four groups were intraperitoneally injected by therapeutic doses of Diminazene aceturate (Berenil): 3.5 mg/kg, Suramine (Naganol): 10.0 mg/kg, Quinapyramine (Antrycide): 5.0 mg/kg and Homidium Bromide (Ethidium Bromide): 1.0 mg/kg. The fifth group of mice was used as a non-treatment control. Animals with heavy parasitic burden were cured by both Naganol and Berenil after 2 and 3 days of therapy, respectively. Unfortunately, Berenil caused death in 2/5 of experimental animals next day of therapy while Naganol showed no detectable toxic effects. Other drugs either failed to cure the infection or produced toxic effects in animals. In conclusion, Naganol is recommended for treatment of Trypanosoma evansi infection of mice.
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