Effects of 1,4- Dioxane on Some Blood Parameters of the Swiss Albino Mice

(Iman Abbas Musa)

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Abstract

Maximum tolerated dose (MTD) of 1,4-dioxane in distilled water (5.7mg/kg) forced fed into male mice twice a week for 8 weeks (total 16 doses). Total red blood cells (RBCs), hemoglobin content (Hb), haematocrite value (Hct,%), mean corpuscular volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC), in addition to the total and differential white blood cells (WBCs) counts were studied as compared to control animals. Multiple exposure of the mice to this specified dose found to express a significant influence in most of blood parameters. Toxicity with 1,4-Dioxane (5.7 mg/kg) induced: 1)- decreases in total RBCs count ,Hb , Hct,% and all investigated blood indices, 2)- The total WBCs was increased significantly and 3) - The differential leucocytes count revealed that a decreased in lymphocytes % and unlike to neutrophils, and monocytes were increased while eosinophil and basophile showed non-significant effects when compared with control group.
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